Hundreds of genes seen sparking to life two days after death

10.1

https://www.newscientist.com/article/2094644-hundreds-of-genes-seen-sparking-to-life-two-days-after-death/

When a doctor declares a person dead, some of their body may still be alive and kicking – at least for a day or two. New evidence in animals suggests that many genes go on working for up to 48 hours after the lights have gone out.

This hustle and bustle has been seen in mice and zebrafish, but there are hints that genes are also active for some time in deceased humans. This discovery could have implications for the safety of organ transplants as well as help pathologists pinpoint a time of death more precisely, perhaps to within minutes of the event.

Peter Noble and Alex Pozhitkov at the University of Washington, Seattle, and their colleagues investigated the activity of genes in the organs of mice and zebrafish immediately after death. They did this by measuring the amount of messenger RNA present. An increase in this mRNA – which genes use to tell cells to make products such as proteins – indicates that genes are more active.

Noble’s team measured mRNA levels in zebrafish, and in brain and liver samples from mice at regular intervals for up to four days after death. They then compared these with mRNA levels measured at the time of death.

As you might expect, overall mRNA levels decreased over time. However, mRNA associated with 548 zebrafish genes and 515 mouse genes saw one or more peaks of activity after death. This meant there was sufficient energy and cellular function for some genes to be switched on and stay active long after the animal died.

These genes cycled through peaks and dips in activity in a “non-winding down” manner, unlike the chaotic behaviour of the rest of the decaying DNA, says Noble.

Hundreds of genes with different functions “woke up” immediately after death. These included fetal development genes that usually turn off after birth, as well as genes that have previously been associated with cancer. Their activity peaked about 24 hours after death.

A similar process might occur in humans. Previous studies have shown that various genes, including those involved in contracting heart muscle and wound healing, were active more than 12 hours after death in humans who had died from multiple trauma, heart attack or suffocation (Forensic Science International, doi.org/bj63).

The fact that some genes associated with cancer are activated after death in animals, might be relevant for reducing the incidence of cancer in people who receive organ transplants, says Noble. People who get a new liver, for example, have more cancers after the treatment than you would expect if they hadn’t had a transplant. The regime of drugs they need to take for life to suppress their immune system so it doesn’t attack the new organ may contribute to this, but Noble says it is worth investigating if activated cancer genes in the donor liver could play a part.

So why do so many genes wake up after death? It is possible that many of the genes become active as part of physiological processes that aid healing or resuscitation after severe injury. For example, after death, some cells might have enough energy to kick-start genes involved in the inflammation process to protect against damage – just as they would if the body were alive.

Alternatively, a rapid decay of genes that normally suppress other genes – such as those involved in embryological development – might allow the usually quiet genes to become active for a short period of time.

For forensic scientists, knowing how gene activity rises and falls at different time points after death is useful for working out when someone died. Measuring mRNA would allow us to nail down the time since death to hours and possibly even minutes, rather than days, helping to reconstruct events surrounding the death.

It is good to see such progress being made in this area, says Graham Williams, consultant forensic geneticist at the University of Huddersfield, UK. “But substantial work is required before this could be applied to case work.”

The research also raises important questions about our definition of death – normally accepted as the cessation of a heartbeat, brain activity and breathing. If genes can be active up to 48 hours after death, is the person technically still alive at that point? “Clearly, studying death will provide new information on the biology of life,” says Noble.

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“New evidence in animals suggests that many genes go on working for up to 48 hours after the lights have gone out.”

interesting stuff..

“The research also raises important questions about our definition of death – normally accepted as the cessation of a heartbeat, brain activity and breathing. If genes can be active up to 48 hours after death, is the person technically still alive at that point?”

401

~ by seeker401 on July 6, 2016.

4 Responses to “Hundreds of genes seen sparking to life two days after death”

  1. THEY ARE SPARKLING AFTER DEATH, BUT NOT BY THE RESURRECTION OF JESUS CHRIST, WHICH LEAVES VERY QUESTIONABLE THOUGHTS. THEY ARE TRYING TO MOCK THE HEAVENLY FATHER YAHVEH, AND TRYING THEIR BEST TO REPLACE JESUS CHRIST, WHICH SHALL END IN TOTAL DISASTER. BOTH OF MY PARENTS ARE DECEASED, BUT I KNOW I SHALL SEE THEM AT THE APPOINTED TIME OF JESUS CHRIST. I WOULD NOT WANT TO SEE THEM BROUGHT BACK TO LIFE THROUGH SATANIC METHODS, EVEN THOUGHT, I WOULD GIVE MY LIFE FOR THEM IF THEY WERE STILL ALIVE, I WOULD PREFER TO DIE. WE SHOULD SINCERELY QUESTION, WHAT IS GOING ON WITH EDUCATION??? SURE PEOPLE SHOULD EDUCATED THEMSELVES, BUT WHAT DOES COME OUT OF THE COLLEGES AND UNIVERSITIES BUT EVIL, AND DESTRUCTION AGAINST THE CREATOR YAHVEH??? IS THIS WHAT ARE WE INVESTING IN EDUCATION IN, ARE WE INVESTING IN EVIL OR EDUCATION FOR THE PURPOSE OF MANKIND KNOWING NO ONE IS GIVEN POWER OF HEAVEN AND EARTH OTHER THAN JESUS CHRIST. MAN SHALL HAVE TO AND MUST COME TO TERMS THAT MAN IS THE CREATION AND NOT THE CREATOR, ETERNAL DIFFERENCE MY FRIENDS.

    http://www.thesleuthjournal.com/technocratic-folly-why-men-will-never-become-gods/

    • the elites want to be immortal..they can have and do anything else they want but they cant live forever and that annoys them..a lot!

      • WHAT A SHAME THEY ONLY HAVE THIS LIFE FULL OF EVIL, CORRUPTION, ETC…, BUT WE ON THE OTHER HAND SHALL NEVER HAVE TO GO THROUGH THE ENDLESS PROCESS OF BEING REINCARNATED, OR KNOW THE PROCESS OF DEATH ANY MORE. WE SHALL HAVE ESCAPED THE ADAMIC AND EVE OF DESTRUCTION. I AM GLAD FOR THIS IS MY LAST BODY TO HAVE IN DEVELOPING TO SERVE THE LORD, AND I SHALL NOT HAVE TO REINCARNATE ANY MORE. THE HEAVENLY FATHER YAHVEH HAS GIVEN ME MANY CHANCES TO REINCARNATE AND COME TO KNOW HIM, AS I SHOULD HAVE, AND THROUGH THESE REINCARNATIONS I HAVE REPENTED AND LEARNED THE TRUTH, AND I ETERNALLY VOW BETWEEN HIM AND THE REST OF THE HUMAN POPULATION, I SHALL ONLY SERVE HIM AND NOT ACCEPT THE MARK OF THE BEAST. ALL OF YOU READING THIS ARE MY WITNESSES AND SHALL HOLD MY ACCOUNTABLE IN EVERY RESPECT. I SHALL HAVE REPENT FOR MY PAST LIVES, AND EVER ENDLESSLY BE THANKFUL TO OUR HEAVENLY FATHER YAHVEH, THAT HE HAS GIVEN ME A CHANCE TO REPENT IN THIS LIFE TIME, EVEN THOUGH I WISH I WERE 100 YEARS OLD AND NOT 63 AT THIS TIME.

  2. Reblogged this on Debatable News: Mainstream to Tinfoil Hat and more and commented:
    The implications are profound. Consider, also, this kind of research: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330983/

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